產(chǎn)品介紹

Huwentoxin-XVI

Huwentoxin-XVI is a selective blocker of N-type Ca²⁺channels

N型Ca²⁺通道選擇性阻斷劑

 is a 39 amino acids peptide that was discovered from the venom of the Chinese tarantula Ornithoctonus huwena.  was shown to be a potent blocker of HVA N-type calcium channels with an IC₅₀ value of 60 nM in rat DRG. The blocking effect appears to be similar to that of  ω-conotoxin-GVIA and ω-conotoxin-MVIIA. Neverthelss,  differs from GVIA and MVIIA thanks to its greater reversibility and its higher selectivity for N-type over P/Q type than MVIIA.

Huwentoxin-XVI技術(shù)資料

氨基酸序列：

Cys¹-Ile-Gly-Glu-Gly-Val-Pro-Cys⁸-Asp-Glu-Asn-Asp-Pro-Arg-Cys¹⁵-Cys¹⁶-Ser-Gly-Leu-Val-Cys²¹-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys³⁶-Tyr-Lys-Lys-OH

二硫鍵：Cys¹-Cys¹⁶, Cys⁸-Cys²¹ and Cys¹⁵-Cys³⁶

長度 (aa)：39

分子式：C₁₉₆H₂₉₂N₅₀O₅₆S₆

分子量（平均）：4437.2 Da

外觀：White lyophilized solid

CAS 號(hào)：Not available

來源：Synthetic

純度：> 98%

產(chǎn)品信息

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